Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration

Seong-Hwan Moon

doi:10.4184/jkss.2007.14.2.120

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Moon: Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration

Original Article

Journal of Korean Spine Surg 2007;14(2):120-128.

Published online: 21 February 2007

DOI: https://doi.org/10.4184/jkss.2007.14.2.120

Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration

Seong-Hwan Moon, M.D.

Department of Orthopaedic Surgery, Brain Korea 21, Yonsei University College of Medicine, Seoul, Korea

Address reprint requests to Seong-Hwan Moon, M.D. Department of Orthopaedic Surgery, Yonsei University College of Medicine 134, Seodaemunku, Shinchondong, Seoul, Korea Tel: 82-2-2228-2188, Fax: 82-2-363-1139, E-mail: shmoon@yumc.yonsei.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intervertebral disc degeneration is main cause of various spinal degenerative conditions, and results in a significant socio-eco-nomic burden and morbidity to those affected. Intervertebral disc degeneration is a multifactorial process that has no known curative method. Hence, various factors that cause intervertebral disc degeneration, especially biochemical ones, were discussed in this study.

Keywords: Intervertebral disc, Degeneration, Biochemical factors

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