Current Status of Translational Research on Functional Dyspepsia

Jae-Ho Park; Jong Wook Kim; Jong Kyu Park; Cheol Min Shin; Kee Wook Jung

doi:10.4166/kjg.2016.68.3.132

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This article has been corrected. See "Corrigendum: Current Status of Translational Research on Functional Dyspepsia" in Volume 68 on page 291.

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Park, Kim, Park, Shin, and Jung: Current Status of Translational Research on Functional Dyspepsia

Review Article

Korean J Gastroenterol 2016;68(3):132-137.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.3.132

Current Status of Translational Research on Functional Dyspepsia

Jae-Ho Park^1,², Jong Wook Kim³, Jong Kyu Park^1,⁴, Cheol Min Shin⁵, Kee Wook Jung^1,⁶

¹Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea

²Department of Gastroenterology, Ulsan University Hospital, Ulsan, Korea

³Division of Gastroenterology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

⁴Department of Gastroenterology, Gangneung Asan Hospital, Gangneung, Korea

⁵Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

⁶Department of Gastroenterology, Asan Medical Center, Seoul, Korea

Correspondence to: Kee Wook Jung, Department of Gastroenterology, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. Tel: +82-2-3010-3900, Fax: +82-2-476-0824, E-mail: jung.keewook30@gmail.com

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite and eating. Functional MRI brain study can expand our knowledge of the brain-gut axis. Finally, immune systems research, including mast cells, can help with comprehensive understanding of FD. The clinical approaches based on these translational research projects are necessary to improve understanding of FD, leading to more effective treatment.

Keywords: Functional dyspepsia, Translational medical research

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Table 1.

Brain Imaging Data in Functional Dyspepsia (FD) Literature

	FD vs. HC			FD subgroups
	Resting	Sham distension	Others	Resting	Distension＞ baseline
SI/SII	↑^35,41	↓⁴⁵
	Interhemi FC ↑³⁷
PFC	↑^35,38,41	↓⁴⁵	Acupuncture ↓⁴⁸	Abused ↑⁴⁶	Non-abused ↑⁴
	Interhemi FC ↑³⁷			Severe ↑³⁵
				AD ↑³⁶
OFC	↑^35,41	↓⁴⁵	Acupuncture ↓⁴⁸	−
	↓^34,38
Insula	↑^35,38,41	↓⁴⁵	Acupuncture ↓⁴⁸	Severe ↑³⁵
	Interhemi FC ↑³⁷			AD ↑³⁶
ACC	↑^35,38,41		Acupuncture ↓⁴⁸	Severe ↑⁵
	↓²
	Interhemi FC ↑³⁷
	FC with insula, PFC ↓⁴⁰
Thalamus	↑^35,38,41			Severe ↑³⁵
	Interhemi FC ↑³⁷			AD ↑³⁶
	PFC ↑⁴⁰
	FC with insula, PFC ↓⁴⁰
Hippo/amygdala	↑⁴¹			Non-abused ↑⁴⁶	Abused ↑⁴⁶

HC, healthy controls; sham, sham distention; SI (II), primary (secondary) somatosensory cortex; FC, functional connectivity; PFC, prefrontal cortex; AD, anxiety and depression; OFC, orbitofrontal cortex; ACC, anterior cingulate cortex; Hippo, hippocampus; Interhemi, interhemispheric.

↑, greater than healthy controls; ↓, lower than healthy controls.

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