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Ra, Sung, Jung, Cha, Baik, Cho, and Kim: A Case of Sustained Cholestasis Caused by Acute A Viral Hepatitis in Dubin-Johnson Syndrome
Case Report
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 59(4): 313-316.

Published online: 23 April 2012

DOI: https://doi.org/10.4166/kjg.2012.59.4.313

A Case of Sustained Cholestasis Caused by Acute A Viral Hepatitis in Dubin-Johnson Syndrome

Sang Ho Ra, Se Yong Sung, Ho Yeon Jung, Jae Hwang Cha, Soon Koo Baik, Mee Yon Cho1, Moon Young Kim

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

1Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Correspondence to: Moon Young Kim, Department of Internal Medicine, Yonsei University Wonju College of Medicine, 162 Ilsan-dong, Wonju 220-701, Korea. Tel: +82-33-741-1225, Fax: +82-33-745-1228, drkimmy@yonsei.ac.kr

Received 18 August 2011       Revised 24 October 2011       Accepted 24 October 2011

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dubin-Johnson syndrome is a rare clinical entity. It shows intermittent symptoms such as chronic or intermittent jaundice, abdominal pain, weakness, nausea, vomiting, anorexia and diarrhea. Symptoms are precipitated or aggravated by pregnancy, alcoholism, surgical procedures and intercurrent disease. Chronic idiopathic jaundice is typical of Dubin-Johnson syndrome and its prognosis is good. We describe a case of prolonged cholestasis for more than 10 months caused by acute A viral hepatitis in a patient with Dubin-Johnson syndrome. It is a first report of cholestasis complicated by acute A viral hepatitis in a patient with Dubin-Johnson syndrome.

Keywords: Jaundice, chronic idiopathic, Hepatitis A, Cholestasis, Hyperbilirubinemia

Figures and Tables

Fig. 1
Microscopically, hepatocytes contained diffuse intracellular deposits of brown pigment (arrows) without evidence of cell damage in liver biopsy in 1995 (H&E, ×200).
kjg-59-313-g001
Fig. 2
(A) Liver computed tomography and (B) endoscopic retrograde cholangiopancreatography showed hepato- splenomegaly and no significant abnormal finding in the biliary tract. Those examinations were performed in acute phase of acute hepatitis A.
kjg-59-313-g002
Fig. 3
The change of serum total and direct bilirubin levels of the patient.
kjg-59-313-g003
Table 1
The Changes of Laboratory Findings
kjg-59-313-i001

Notes

Financial support: None.

Conflict of interest: None.

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