Correlation between Androgen Deficiency on the Aging Males Questionnaire and the Aging Males' Symptoms Scale and Their Relationship with Serum Testosterone

Dong Soo Park; Tae Beom Kim; Ja Hyun Ku; Soo Woong Kim; Jae-Seung Paick

doi:10.4111/kju.2008.49.11.1035

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Park, Kim, Ku, Kim, and Paick: Correlation between Androgen Deficiency on the Aging Males Questionnaire and the Aging Males' Symptoms Scale and Their Relationship with Serum Testosterone

Original Article

Korean Journal of Urology

Korean Journal of Urology 2008; 49(11): 1035-1040.

Published online: 30 November 2008

DOI: https://doi.org/10.4111/kju.2008.49.11.1035

Correlation between Androgen Deficiency on the Aging Males Questionnaire and the Aging Males' Symptoms Scale and Their Relationship with Serum Testosterone

Dong Soo Park, Tae Beom Kim¹, Ja Hyun Ku, Soo Woong Kim, Jae-Seung Paick

Department of Urology, Seoul National University College of Medicine, Seoul, Korea.

¹Department of Urology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.

jspaick@snu.ac.kr

Received 8 July 2008 Accepted 17 July 2008

Abstract

Purpose

The aim of this study is to analyze the correlation between the Androgen Deficiency in Aging Males (ADAM) questionnaire and the Aging Males' Symptoms (AMS) scale and to determine their relationship with the serum testosterone level.

Materials and Methods

We retrospectively reviewed the medical records of the patients who took the self-administered ADAM questionnaire, the AMS scale and the International Index of Erectile Function (IIEF) questionnaire. We enrolled a total of 265 patients older than 40 years who presented a positive result for the ADAM questionnaire (defined as a 'yes' answer to question 1 or 7, or a 'yes' answer to at least three of the other questions). Blood tests were performed, including the total testosterone, prolactin, the lipid profiles and the fasting glucose level.

Results

The psychological subscale of the AMS scale was correlated with ADAM questions 2, 3, 5, 7, 8 and 10 (p<0.005) and the somato-vegetative subscale was correlated with questions 2, 3, 5, 6, 8 and 10 (p<0.05). The sexual subscale was correlated with questions 1, 2, 5, 6, 7, 8 and 10 (p<0.05). Statistically significant differences were found for the IIEF questionnaire scores between the patients with 'yes' and 'no' answer to ADAM question 1 and 7 (p<0.05). The IIEF questionnaire scores were significantly lower for the men with a sexual subscale score 11-25 on the AMS scale (p<0.05). The total testosterone was not correlated with the ADAM, AMS and IIEF questionnaire but the total testosterone demonstrated a significantly negative correlation with weight, abdominal circumference, body mass index (BMI) and triglyceride (p<0.05).

Conclusions

This analysis revealed that the ADAM questionnaire and the AMS scale have a significant relationship, and especially the sexual function domain of the two questionnaires showed correlation with the IIEF questionnaire. Serum testosterone was related with weight, abdominal circumference, BMI and triglyceride.

Keywords: Hypogonadism, Questionnaires, Testosterone

Figures and Tables

Table 1

Patients' characteristics

SD: standard deviation, BMI: body mass index, HDL: high density lipoprotein, LDL: low density lipoprotein, AMS: Aging Males' Symptoms, IIEF: International Index of Erectile Function

Table 2

Correlation between the ADAM questionnaire and the AMS scale

AMS: Aging Males' Symptoms, ADAM: Androgen Deficiency in Aging Males

Table 3

Correlation between the ADAM questionnaire questions 1 and 7 and the IIEF questionnaire

ADAM: Androgen Deficiency in Aging Males, IIEF: International Index of Erectile Function

Table 4

Correlation between the sexual subscale of the AMS scale and the IIEF questionnaire

AMS: Aging Males' Symptoms, IIEF: International Index of Erectile Function

Table 5

Relationship with serum testosterone

BMI: body mass index, AMS: Aging Males' Symptoms, ADAM: Androgen Deficiency in Aging Males, IIEF: International Index of Erectile Function, ns: not significant

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