Journal List > Endocrinol Metab > v.27(4) > 1085980

Kim, Kim, Kim, Huh, Lee, Park, Choe, Park, Lee, Hong, Lee, Kang, Cha, Lee, and Lee: A Case of Latent Autoimmune Diabetes in Adults Developed after Surgical Cure of Growth Hormone Secreting Pituitary Tumor

Abstract

Acromegaly is generally caused by a benign growth hormone (GH)-secreting pituitary adenoma. It is characterized by a wide range of complications; cardiovascular, respiratory, bone and joint, and metabolic complications. Among them, impaired glucose tolerance and diabetes mellitus, due to GH-induced insulin resistance, has been reported in approximately 16-46% and 19-56%. They are usually improved following the treatment of acromegaly, surgical or medical therapy. We report a first case of 36-year-old man who was paradoxically diagnosed with GAD antibody positive latent autoimmune diabetes in adults (LADA) after the surgical cure of acromegaly.

Figures and Tables

Fig. 1
A 75 g oral glucose tolerance tests (pre- and post-operation). (A) A 75 g oral glucose tolerance test for serum glucose levels; This patient was confirmed acromegaly with insulin-independent diabetes mellitus. It is cured after tumor resection. (B) A 75 g oral glucose tolerance test for growth hormone as a confirmation test for acromegaly remission. There was excessive secretion of growth hormone (GH) which was decreased after tumor resection (GH normal range, 0-9.5 ng/mL).
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Fig. 2
Sella magnetic resonance imaging and dynamic. (A) Pre-operation (November 25, 2009). (B) One year after operation (March 9, 2011).
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