Journal List > J Korean Ophthalmol Soc > v.55(9) > 1009770

Kim and Oh: Effects of Topical Tranilast on Corneal Haze with the Pentacam® after Photorefractive Keratectomy

Abstract

Purpose

To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam® after photorefractive keratectomy (PRK).

Methods

A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes <-5 D and ≥-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam® and compared between the 2 groups.

Results

Statistical differences were not found in preoperative data in the tranilast or control groups (all p > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (p < 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group (p > 0.05).

Conclusions

The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam® can provide a useful objective measure of corneal haze.

References

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Figure 1.
Scheimpflug image and slit-lamp photograph of a cornea after PRK.
jkos-55-1277f1.tif
Figure 2.
Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.64).
jkos-55-1277f2.tif
Figure 3.
Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.66).
jkos-55-1277f3.tif
Figure 4.
Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.72).
jkos-55-1277f4.tif
Figure 5.
Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.69).
jkos-55-1277f5.tif
Table 1.
Preoperative data of myopic eyes <-5 D
Group
p-value
Tranilast Control
Age (years) 26.63 ± 5.54
Sex (M/F) 15 (7/8)
CCT (μm) 524.63 ± 23.51 527.25 ± 24.31 0.31
Sphere (diopter) −3.26 ± 0.94 −3.25 ± 0.82 0.96
Cylinder (diopter) −0.66 ± 0.46 −0.60 ± 0.42 0.51

Values are presented as mean ± SD.

CCT = central corneal thickness.

Table 2.
Postoperative data of myopic eyes <-5 D
Group
p-value
Tranilast Control
UCVA (log MAR) 0.03 ± 0.07 0.04 ± 0.06 0.74
BCVA (log MAR) 0.00 ± 0.00 0.00 ± 0.00 1.00
MRSE (diopter) −0.18 ± 0.31 −0.19 ± 0.29 0.91
CCT (μm) 463.38 ± 30.00 465.56 ± 30.67 0.50

Values are presented as mean ± SD.

UCVA = uncorrected visual acuity; BCVA = best corrected visual acuity; MRSE = manifest refraction spherical equivalent; CCT = central corneal thickness.

Table 3.
Mean maximum density values measured with the Pentacam® for myopic eyes <-5 D
Distance from apex Tranilast Control p-value
0 mm 29.01 ± 2.82 29.50 ± 3.13 0.46
1 mm 27.94 ± 3.10 28.14 ± 2.94 0.69
2 mm 26.29 ± 2.75 26.20 ± 2.14 0.83
3 mm 22.78 ± 2.62 23.07 ± 2.33 0.39

Values are presented as mean ± SD.

Table 4.
Preoperative data of myopic eyes ≥-5 D
Group
p-value
Tranilast Control
Age (years) 22.14 ± 8.47
Sex (M/F) 15 (7/8)
CCT (μm) 540.93 ± 22.43 543.71 ± 19.57 0.31
Sphere (diopter) −6.02 ± 0.21 −5.74 ± 0.24 0.26
Cylinder (diopter) −1.62 ± 0.56 −1.52 ± 0.68 0.46

Values are presented as mean ± SD.

CCT = central corneal thickness.

Table 5.
Postoperative data of myopic eyes ≥-5 D
Group
p-value
Tranilast Control
UCVA (log MAR) 0.05 ± 0.09 0.04 ± 0.08 0.75
BCVA (log MAR) 0.00 ± 0.00 0.00 ± 0.00 1.00
MRSE (diopter) −0.21 ± 0.27 −0.23 ± 0.32 0.90
CCT 427.86 ± 21.10 432.07 ± 22.20 0.15

Values are presented as mean ± SD.

UCVA = uncorrected visual acuity; BCVA = best corrected visual acuity; MRSE = manifest refraction spherical equivalent; CCT = central corneal thickness.

Table 6.
Mean maximum density values measured with the Pentacam® for myopic eyes ≥-5 D
Distance from apex Tranilast Control p-value
0 mm 29.16 ± 2.74 29.03 ± 2.00 0.85
1 mm 27.19 ± 4.17 27.39 ± 2.17 0.83
2 mm 25.75 ± 3.41 26.13 ± 2.55 0.75
3 mm 23.36 ± 1.64 23.06 ± 2.05 0.59

Values are presented as mean ± SD.

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