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Abstract
Purpose
To report a case of intravitreal bevacizumab injection for choroidal neovascularization following direct laser photocoagulation for central serous chorioretinopathy.
Case summary
A 44-year-old male patient with an 8-month history of metamorphopsia in his left eye visited our clinic and was diagnosed with central serous chorioretinopathy after performing refraction, fundus examination, fluorescein angiography (FAG) and optical coherence tomography (OCT). After 1 month, laser photocoagulation of the leaking point observed on the FAG was performed. After 8 weeks following laser photocoagulation, visual acuity was reduced to 0.4, subretinal hemorrhage accompanied by choroidal neovascularization was observed on FAG and OCT, and an intravitreal bevacizumab injection was administered. After 4 weeks following the injection, macular edema and subretinal hemorrhage decreased, visual acuity increased to 1.0 and was maintained properly. However, after 2 years, the central serous chorioretinopathy recurred and after 3 months, healed spontaneously.
Conclusions
Intravitreal bevacizumab injection is a safe and effective treatment for secondary choroidal neovascularization occurring after direct laser photocoagulation for central serous chorioretinopathy. In addition, a single treatment can maintain the patient's status with no recurrence of choroidal neovascularization over a long-term period.
Figures and Tables
Figure 1
Initial fundus photographs and fluorescein angiographs. The right eye shows retinal pigment epithelium atrophy at the macula (A). The left eye shows elevated serous lesion involving the macula (B). FAG of the right eye shows atrophic tract and window defect around the macular area in the late phase (C). FAG of the left eye shows a smokestack appearance around the macular area in the late phase (D). FAG = fluorescein angiograph.
Figure 2
The baseline optical coherence tomography (OCT) of the left eye shows a neurosensory retinal detachment in the macular region (A), OCT of the left eye at four weeks after focal laser photocoagulation shows resolution of neurosensory retinal detachment (B).
Figure 3
Fundus photograph of the left eye at two months after laser photocoagulation shows subretinal hemorrhage at the superotemporal area from the fovea involving macula (A). Fluorescein angiograph of the left eye at two months after laser photocoagulation shows a leakage with blockage by blood at the superotemporal area from the fovea (B). Optical coherence tomography of the left eye at two months after laser photocoagulation shows subretinal hemorrhage and choroidal neovascular membrane (C).
Figure 4
Fundus photograph of the left eye at five weeks after intravitreal bevasizumab injection shows decreased subretinal hemorrhage at the superotemporal area from the fovea (A). Fluorescein angiograph of the left eye at five weeks after intravitreal bevasizumab injection shows stained lesion without leakage at the superotemporal area from the fovea (B).
Figure 5
OCT of the left eye at two years after intravitreal bevasizumab injection shows a neurosensory retinal detachment in the macular region (A). OCT of the left eye at four months after a neurosensory retinal detachment shows resolution of neurosensory retinal detachment (B). OCT = optical coherence tomography.
References
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