Journal List > J Korean Foot Ankle Soc > v.18(4) > 1043312

Park: Effect of Antiplatelets in Diabetic Peripheral Vasculopathy: Comparison by Ankle-Brachial Index and Peak Wave Velocity

Abstract

Purpose:

The purpose of this study is to confirm the effect of antiplatelet drugs in diabetic peripheral vasculopathy in diabetic foot patients.

Materials and Methods:

We designed a retrospective study in diabetic foot patients with diabetic peripheral vasculopathy. From October 2007 to December 2013, 278 cases in 139 patients who took antiplatelet drugs over at least a six-month period were included in this study. We categorized these patients according to the type of drug used. The efficacy of antiplatelet drugs was evaluated using ankle-brachial index (ABI) and pulse wave velocity (PWV).

Results:

Only the aspirin group showed a statistically significant increase of ABI after antiplatelet therapy (1.10±0.12 to 1.12±0.11). In addition, only the cilostazol group showed a statistically significant decrease of PWV after antiplatelet therapy (1,701.20±396.56 to 1,627.42±324.98).

Conclusion:

Aspirin and cilostazol may be used in treatment of diabetic peripheral vasculopathy, whereas dual antiplatelet therapy with aspirin and clopidogrel has no specific benefits in diabetic peripheral vasculopathy.

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Table 1.
Baseline Characteristics of the Study Subjects
Parameter Sarpogrelate Aspirin Aspirin+clopidogrel Cilostazol p-value
Number of patients 18 81 15 25
Sex (male/female) 6/12 31/50 1/14 7/18 0.110
Age (yr) 58.89±10.31 61.45±11.62 67.07±12.13 60.28±10.20 0.185
HbA1C (%) 7.02±0.99 7.11±1.01 7.60±1.48 6.75±0.77 0.101
Diabetes mellitus duration (yr) 10.72±8.33 11.35±8.27 13.93±7.53 10.61±8.15 0.621
Social and medical history
Smoking 5 (27.78) 14 (17.28) 4 (26.67) 5 (20.00) 0.617
Hypertension 7 (38.89) 45 (55.56) 9 (60.00) 8 (32.00) 0.126
Hyperlipidemia 5 (27.78) 28 (34.57) 0 (0) 9 (36.00) 0.053
Cardiovascular accident 1 (5.56) 6 (7.41) 3 (20.00) 1 (4.00) 0.321

Values are presented as number, mean±standard deviation, or patients number (%).

Table 2.
Changes of Ankle-Brachial Index (ABI) over 6 Months in Patients Treated with Antiplatelet Therapy
Medication Number of cases ABI p-value
Baseline Follow-up
Sarpogrelate 36 1.13±0.08 1.15±0.07 0.063
Aspirin 162 1.10±0.12 1.12±0.11 0.022
Aspirin+clopidogrel 30 0.92±0.31 0.87±0.34 0.267
Cilostazol 50 1.12±0.12 1.10±0.11 0.153

Values are presented as number or mean±standard deviation.

Table 3.
Changes of Pulse Wave Velocity (PWV) over 6 Months in Patients Treated with Antiplatelet Therapy
Medication Number of cases PWV p-value
Baseline Follow-up
Sarpogrelate 36 1,625.53±368.88 1,689.86±309.49 0.112
Aspirin 162 1,624.14±438.74 1,626.61±342.18 0.939
Aspirin+clopidogrel 30 1,686.40±632.02 1,542.17±1168.55 0.544
Cilostazol 50 1,701.20±396.56 1,627.42±324.98 0.029

Values are presented as number or mean±standard deviation.

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