Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

Jee Eun Kwon; Young Kim; Seonghyup Hyun; Hoyoun Won; Seung Yong Shin; Kwang Je Lee; Sang-Wook Kim; Tae Ho Kim; Chee Jeong Kim

doi:10.12997/jla.2014.3.1.21

Journal List > J Lipid Atheroscler > v.3(1) > 1059540

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Kwon, Kim, Hyun, Won, Shin, Lee, Kim, Kim, and Kim: Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

Original Article

Journal of Lipid and Atherosclerosis 2014; 3(1): 21-28.

Published online: 30 June 2014

DOI: https://doi.org/10.12997/jla.2014.3.1.21

Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

Jee Eun Kwon, Young Kim, Seonghyup Hyun, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Sang-Wook Kim, Tae Ho Kim, Chee Jeong Kim

Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.

Corresponding Author: Chee Jeong Kim, Division of Cardiology, Department of Internal Medicine, Chung-Ang University Hospital, 224-1 Heukseokdong, Dongjakku, Seoul 156-755, Korea. Tel: +82-2-6299-1398, Fax: +82-2-822-2769, cjkim@cau.ac.kr

Received 28 April 2014 Revised 12 May 2014 Accepted 16 May 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients.

Methods

A total of 909 consecutive patients were enrolled prospectively according to the criteria of National Cholesterol Education Program guidelines. Lipid profiles were obtained before and 2 months after statin therapy.

Results

Atorvastatin 10 mg (n=260), lovastatin 20 mg (n=145), pitavastatin 2 mg (n=80), pravastatin 20 mg (n=28), rosuvastatin 5 mg (n=145), and simvastatin 20 mg (n=208) reduced low density lipoprotein (LDL) cholesterol by -41.8±11.0%, -33.8±12.8%, -39.3±10.8%, -31.5±8.9%, -48.8±12.3%, and -42.8±13.5%, respectively. LDL cholesterol less than 130 mg/dL was achieved in 90.3%, 76.9%, 88.5%, 85.2%, 97.2%, and 94.2%, respectively. The reduction of LDL cholesterol by 30% or more was obtained in 84.4%, 60.7%, 81.6%, 63.0%, 93.0%, and 83.5%, respectively. LDL cholesterol less than 70 mg/dL or the reduction by 50% or more was observed in a small portion of patients and was variable according to the different types of statins.

Conclusion

A low dose statin was enough to manage dyslipidemia in most Korean patients with low to moderate risks and was even effective in a subpopulation of high risk patients.

Keywords: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, Hypercholesterolemia, LDL Cholesterol

Figures and Tables

Table 1

Comparisons of baseline clinical and laboratory characteristics among statin groups

Data are presented as the Mean±SD, BMI; body mass index, HDL-C; high density lipoprotein cholesterol, LDL-C; low density lipoprotein cholesterol, AST; aspartate aminotransferase, ALT; alanine aminotransferase

Table 2

Percent changes of lipid profiles among statin groups

Data are presented as the Mean±SD, ^*; p<0.05, HDL-C; high density lipoprotein cholesterol, LDL-C; low density lipoprotein cholesterol

Table 3

Parameters associated with percent changes of lipid profiles

HDL-C; high density lipoprotein cholesterol, LDL-C; low density lipoprotein cholesterol, BMI; body mass index, AST; aspartate aminotransferase, ALT; alanine aminotransferase

Table 4

Percent of patients achieving LDL-C targets recommended by major guidelines for lipid management among statin groups

HDL-C; high density lipoprotein cholesterol, LDL-C; low density lipoprotein cholesterol

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