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Lee and Rhee: An Experimental Study of the Effect of Radiation and Cis-Dichlorodiammineplatinum(II) on the Rat Kidney
Original Article

The Ewha Medical Journal 1992; 15(2): 123-131.

Published online: 24 July 2015

DOI: https://doi.org/10.12771/emj.1992.15.2.123

An Experimental Study of the Effect of Radiation and Cis-Dichlorodiammineplatinum(II) on the Rat Kidney

Kyung Ja Lee, Chung Sik Rhee

Department of Radiology, College of Medicine, Ewha Womans University, Korea.

Copyright © 1992. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of radiation and Cis-dichlorodiammineplatinum(II)(Cis-DDP) in combination was studied in the renal histopathologic changes of the rat. The histologic evaluation was performed 30 days after the single dose of Cis-DDP(2.5mg/kg) and X-ray irradiation(6,8,10 Gy. single dose) and combination of Cis-DDP and X-ray. For the combined treatment a single dose of Cis-DDP was given 30 min before or immediately after radiation(pre-and post-radiation group).
Cis-DDP alone, showed mild necrosis, degeneration, hemorrhage and focal inflammatory cell infiltrations in the renal tubule and mild congestion of the glomerulus. In radiation alone. edema of the glomerulus and tubular degeneration was seen with 10 Gy and 8 Gy, respectively. With combined chemotherapy and radiation, edema of glomeruli and tubular degeneration was seen with 8 and 6 Gy irradiation, respectively in both pre-and post-radiation group. Tubular necrosis and degeneration and interstitial inflammatory cell infiltrations were more marked in pre-radiation group. When the edema of glomerulus was used as an endpoint, the enhancement ratio was 1.25 in normal rat kidney.

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