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       Journal List > J Korean Med Sci > v.23(4); Aug 2008
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J Korean Med Sci. 2008 Aug;23(4):657-661.
Published online 2008 August 25.  doi: 10.3346/jkms.2008.23.4.657.
Copyright © 2008 The Korean Academy of Medical Sciences
Serum Anti-Müllerian Hormone and Inhibin B Levels at Ovulation Triggering Day Can Predict the Number of Immature Oocytes Retrieved in In Vitro Fertilization Cycles
Byung Chul Jee,* Seung Yup Ku,† Chang Suk Suh,*† Ki Chul Kim,‡ Won Don Lee,§ Seok Hyun Kim,† and The Seoul National University College of Medicine Assisted Reproductive Technology (SMART) Study Group
*Department of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seongnam, Korea.
†Department of Obstetrics and Gynecology, Seoul National University, College of Medicine, Seoul, Korea.
‡Hamchoon Women's Clinics, Seoul, Korea.
§Maria Infertility Clinics, Seoul, Korea.

Address for correspondence: Seok Hyun Kim, M.D. Department of Obstetrics and Gynecology, Seoul National University, College of Medicine, 28 Yeongeondong, Jongno-gu, Seoul 110-744, Korea. Tel: +82.2-2702-3773, Fax: +82.2-762-3599, Email: seokhyun@snu.ac.kr
Received July 19, 2007; Accepted December 27, 2007.

Abstract

The aim of this study was to investigate whether serum levels of anti-Müllerian hormone (AMH) and inhibin B at ovulation triggering day correlate with the number of immature oocytes obtained from stimulated in vitro fertilization (IVF) cycles. Fiftynine consecutive cycles of ovarian hyperstimulation and IVF were selected from 45 women who had tubal (n=18) or unexplained infertility (n=27) and obtained at least one oocyte. Serum levels of AMH and inhibin B at ovulation triggering day were measured by enzyme-linked immunosorbent assay (ELISA). Univariate analysis and multiple regressions revealed that serum AMH or inhibin B levels were significantly correlated with immature oocyte count and the correlation coefficients were higher compared to the mature oocyte count. Serum AMH and inhibin B levels on triggering day seems to be more closely related with the immature oocyte count and thus could be good predictors to determine the immature oocyte count in IVF cycle.

Keywords: Anti-Müllerian Hormone, Inhibin B, Immature Oocyte, Fertilization In Vitro.
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